The size of the largest U.S. deals was smaller than in recent weeks, and heavily featured cybersecurity- and privacy-focused startups. This includes the week's biggest round ' a $375 million Series B for consumer privacy and security platform Cloaked. Other areas that attracted good-sized financings included AI infrastructure, biotech, healthcare, and robotics. 1. Cloaked, $375M, privacy: Cloaked, a provider of consumer privacy and security tools, raised $375 million in Series B funding led by General Catalyst and Liberty City Ventures. Founded in 2020, the Massachusetts-based company sells monthly subscriptions for individuals and families. 2. Frore Systems, $143M, AI infrastructure: Frore Systems, a developer of integrated cooling architecture for AI computing and networking hardware, announced that it closed on $143 million in Series D funding. MVP Ventures led the financing, which set a $1.64 billion valuation for the 8-year-old, San Jose-based company. 3. (tied) XBow, $120M, cybersecurity: Seattle-based XBow, a provider of autonomous security testing technology, picked up $120 million in Series C funding. DFJ Growth and Northzone led the round, which values the 2-year-old company at over $1 billion....

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Blue Origin, the space conglomerate founded by Amazon chair Jeff Bezos, has asked the U.S. government for permission to launch a network of more than 50,000 satellites that will act as a data center in orbit. In a March 19 document filed with the Federal Communications Commission (FCC), Blue Origin's attorneys described 'Project Sunrise' as a network of spacecraft that will perform advanced computation in orbit to 'ease mounting pressure on U.S. communities and natural resources by shifting energy ' and water-intensive compute away from terrestrial data centers.' Blue Origin's filing did not describe its plans for the satellites in detail, so it's hard to know how much computing power the company is aiming to generate in space. It does note that Blue Origin plans to use another satellite constellation it is seeking to build, called TeraWave, as a high-throughput communications backbone for the data satellites. Shifting massive compute to space is attractive because solar energy is free to harvest and, once in orbit, there are fewer regulations restricting corporate activities. Entrepreneurs behind these projects envision a future where AI tools are widespread and imagine that much of the inference work behind them will be outsourced to orbit....

The blobfish, once considered the ugliest animal in the world, has since had quite the redemption arc. Years after it was first discovered, scientists realized that the deep-sea creature appeared so unnervingly blobby only because it went through an extreme change in pressure when it was brought up to the surface. In its natural environment, 4,000 feet underwater, the fish looks perfectly handsome. Structural biologists, whose goal is to deduce a molecule's structure and function within a cell, face the risk of making a similar mistake. If biomolecular complexes are extracted from the cell, better-quality images can be obtained, but the molecules may not look natural. On the other hand, studying molecules without disrupting their environment at all is technically challenging, like filming deep underwater. A new method, called purification-free ribosome imaging from subcellular mixtures (cryoPRISM), offers an appealing compromise. Developed by graduate students Mira May and Gabriela Lopez-Perez in the Davis lab in the MIT Department of Biology and recently published in PNAS, the technique allows biologists to visualize molecular complexes without taking them too far out of their natural context....