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Cellular senescence and aging
Research Group in Cell-biology
 
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Cellular Senescence: Aging, Cancer, and Injury
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Research Support, Non-U.S. Gov't

Aging / metabolism

Aging / physiology*

Animals

Cell Proliferation / physiology

Cell Transformation, Neoplastic / metabolism*

Cellular Senescence / physiology*

Humans

Neoplasms / metabolism*

Wound Healing / physiology*

Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that ....
Cellular aging beyond cellular senescence: Markers of senescence prior to cell c ...
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Aging / metabolism*

Animals

Biomarkers / metabolism

Cell Cycle Checkpoints / physiology*

Cell Division / physiology

Cell Proliferation / physiology

Cell Size

Cellular Senescence / physiology*

DNA Breaks, Double-Stranded

Humans

Phenotype

Telomere Shortening / physiology

Biomarkers

The field of research on cellular senescence experienced a rapid expansion from being primarily focused on in vitro aspects of aging to the vast territories of animal and clinical research. ....
Cellular senescence in brain aging and neurodegeneration
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Research Support, Non-U.S. Gov't

Aging* / physiology

Brain / physiology

Cell Cycle Checkpoints

Cellular Senescence / physiology

Humans

Neurodegenerative Diseases*

Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells naturally accumulate....
Aging of the cells: Insight into cellular senescence and detection Methods
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Aging

Cellular Senescence / physiology*

Humans

Cellular theory of aging states that human aging is the result of cellular aging, in which an increasing proportion of cells reach senescence. Senescence, from the Latin word senex, means "g....