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Cell-biology
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Cellular senescence: a key therapeutic target in aging and diseases
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Research Support, Non-U.S. Gov't

Research Support, N.I.H., Extramural

Aging* / genetics

Aging* / pathology

Animals

Cell Cycle

Cellular Senescence* / physiology

Mice

Mice, Transgenic

Wound Healing

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogeni....
Aging, cellular senescence, and cancer
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Aging / physiology*

Animals

Cellular Senescence / physiology*

DNA Damage / physiology

Disease Models, Animal

Humans

Neoplasms / physiopathology*

Stress, Physiological / physiology

For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging....
Skin Aging, Cellular Senescence and Natural Polyphenols
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Aging / physiology

COVID-19

Cellular Senescence / drug effects*

Cellular Senescence / physiology*

Fibroblasts

Humans

Keratinocytes

Melanocytes

Polyphenols / pharmacology*

SARS-CoV-2

Skin / pathology

Skin Aging / drug effects*

Skin Aging / pathology

Skin Aging / physiology*

Polyphenols

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found to accumulate with age and ....
Hallmarks of Cellular Senescence
Posted by Mark Field in Cell-biology and Cellular senescence and aging

Aging / genetics*

Aging / metabolism*

Biomarkers / metabolism*

Cellular Senescence / genetics*

DNA Damage

Genetic Markers

Humans

Phenotype

Biomarkers

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative ....