Back in the 1980s, when Shimon Sakaguchi was a young researcher in immunology, he found it difficult to get his research funded. Now, his pioneering work which explains how our immune system knows when and what to attack, has won him a Nobel prize. Sakaguchi, along with American researchers Mary Brunkow and Fred Ramsdell, were jointly awarded the 2025 Nobel prize in physiology or medicine for their work on regulatory T-cells, known as T-regs for short, a special class of immune cells which prevent our immune system from attacking our own body. Sakaguchi was inspired by an experiment involving newborn mice conducted by his colleagues at the Aichi Cancer Center Research Institute in Nagoya. They'd removed the thymus from mice three days after they were born. It was already known that the thymus is important in the development of immune self-tolerance: it's where T-cells, a type of lymphocyte or white blood cell, that could attack the body are isolated and destroyed. Sakaguchi was...
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