In the winter of 168 C.E., the famed Greek physician Galen arrived in Aquileia, an Italian city on the northern edge of the Adriatic. The city had grown large since its founding as a Roman colony, but during the 200-year Pax Romana, its fortifications had been allowed to deteriorate. After an armed group of migrating Germanic peoples had crossed the Danube a year earlier, the Roman co-emperors, Marcus Aurelius and Lucius Verus, had rushed to the city, raising two legions and rebuilding its defenses; they planned to use it as a base of operations against the invaders. Galen had been summoned, however, to help fight a different kind of invader. A plague, likely an early variant of smallpox, had traveled to Aquileia with the troops, and held the city in its grip. The emperors fled, but Verus succumbed to the disease on the road to Rome. Galen tried to slow the wave of illness, but most of the people in Aquileia perished. They represented just a sliver of the eventual victims of the...
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