When doctors and scientists want to see inside a body, magnetic resonance imaging (MRI) is a powerful tool. MRI can noninvasively capture detailed images of the body's muscles, organs, and bones. It can monitor blood flow to generate a map of brain activity. And with new sensors developed by bioengineers at MIT, MRI can track the kinds of molecules that make our brains and bodies work. In the May 13 issue of the journal Nature Biomedical Engineering, a team led by Alan Jasanoff, the Eugene McDermott Professor in the Brain Sciences and Human Behavior at MIT, reports on their new sensors, which can brighten or dim MRI signals in response to specific molecular targets. The probes are designed to amplify the effect that each target molecule has on MRI signal, dramatically improving sensitivity over previous small-molecule sensors. Jasanoff, who is also an associate investigator at the McGovern Institute for Brain Research, says the approach his team used should enable the development of...
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