AlphaFold is now capable of predicting homodimeric complexes, including those formed by the transcription elongation factor Eaf, the N'terminal region of which is shown here.Credit: Google DeepMind/EMBL-EBI (CC-BY-4.0) For the first time, the AlphaFold protein-structure database will include predictions of complexes of proteins ' with the addition of 1.7 million 'homodimers' comprising two interacting strands of the same molecule. The freely available database, maintained by the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, currently holds around 200 million predictions of individual protein structures, made using the AlphaFold2 artificial-intelligence tool, developed by London-based firm Google DeepMind. Since its release in 2021, this repository has become a bedrock in discovery and a first port of call for research projects that try to understand life at the molecular level. But previous iterations of the database lacked...
learn more
