Security guard Larry Daley infiltrates the Smithsonian Institution in order to rescue Jedediah and Octavius, who have been shipped to the museum by mistake.Ben Stiller returns as night watchman Larry Daily, now a successful business man, who gets back to the museum just in time to find that he needs to get his friends out of trouble. This new installment takes us to the Smithsonian, and introduces us to new characters, such as Amelia Earhart, General Custer, and many more!